DBCO-PEG4-NHS Ester
CAS: 1427004-19-0
Description:
DBCO-PEG4-NHS ester is a functional linker featuring a dibenzocyclooctyne group and an NHS ester attached via a PEG4 (polyethylene glycol) spacer. The DBCO group allows for copper-free click chemistry with azide-functionalized molecules, while the NHS ester reacts efficiently with primary amines, enabling stable bioconjugation to proteins, peptides, and other biomolecules.
Key Features:
- DBCO Group: Facilitates copper-free click chemistry with azide groups, ideal for bioorthogonal labeling in live cells and complex environments.
- NHS Ester: Binds to primary amines on biomolecules, forming stable amide bonds for effective conjugation.
- PEG4 Spacer: Enhances solubility, flexibility, and reduces steric hindrance, improving the linker’s biocompatibility.
Applications:
- Bioconjugation: Attaches biomolecules through amine and azide groups, widely used in labeling and modification.
- Drug Delivery Systems: Enables creation of targeted drug conjugates for precise delivery.
- Protein and Antibody Labeling: Suitable for stable and bioorthogonal labeling in live-cell imaging and in vivo studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
