DBCO-PEG₂-NHS Ester (CAS: 2585653-12-7)
DBCO-PEG₂-NHS Ester is a versatile reagent designed for bioconjugation applications. It combines a dibenzocyclooctyne (DBCO) group for copper-free click chemistry with an N-hydroxysuccinimide (NHS) ester for amine-specific labeling, making it ideal for linking biomolecules.
Key Features:
- Dual Functional Groups:
- NHS Ester: Reacts with primary amines (e.g., lysine residues) to form stable amide bonds.
- DBCO Group: Enables copper-free click chemistry with azide-containing molecules for rapid and specific conjugation.
- PEG Spacer:
- Enhances solubility and biocompatibility.
- Reduces steric hindrance for efficient labeling.
Applications:
- Protein and Peptide Labeling:
- Attaches functional groups, fluorescent dyes, or drugs to proteins and peptides for research or therapeutic use.
- Antibody-Drug Conjugates (ADCs):
- Links cytotoxic drugs to antibodies for targeted cancer therapy.
- Surface Modification:
- Functionalizes surfaces like nanoparticles or biosensors for improved specificity and sensitivity in diagnostics.
- Molecular Crosslinking:
- Crosslinks biomolecules to stabilize protein complexes and study molecular interactions.
DBCO PEG2 NHS ester is widely used in chemical biology, diagnostics, and drug development. Its ability to link biomolecules efficiently and selectively makes it essential for advanced research and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
