DBCO-PEG1-NHS ester
This product is a compact heterobifunctional linker containing a dibenzocyclooctyne (DBCO) group, a short PEG1 spacer, and an NHS ester. The DBCO enables rapid, copper-free SPAAC click chemistry with azides, while the NHS ester reacts efficiently with primary amines to form stable amide bonds. The PEG1 unit provides minimal added length while improving solubility, making this a useful tool for dual-reactive conjugation in compact systems.
Key Features and Benefits
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DBCO Group: Performs ultrafast, copper-free SPAAC click chemistry with azides.
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NHS Ester: Couples efficiently with primary amines (e.g., lysines, N-termini).
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PEG1 Spacer: Provides compact hydrophilicity and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry and amine conjugation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Protein and Antibody Labeling: Couples NHS ester to amines for site-specific biotinylation or probe attachment.
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Bioconjugation: Links azide- and amine-functionalized biomolecules.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Serves as a compact linker for therapeutic design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid prolonged exposure to aqueous buffers.
This product combines ultrafast click reactivity with amine coupling in a minimal PEG1 design, specifically offering a compact and efficient linker for bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
