DBCO-PEG-Maleimide, MW 5K is a bioconjugation DBCO reagent that has gained significant interest in the field of pharmaceutical research and development. This molecule is composed of three functional groups, namely maleimide, PEG, and DBCO. The maleimide group is a well-known thiol-reactive group that reacts with free thiols (-SH) of cysteine residues in proteins, peptides, and other biomolecules. The PEG group, or polyethylene glycol, is a versatile polymer that can increase solubility, stability, and biocompatibility of bioconjugates. The DBCO group, or dibenzocyclooctyne, is a strained alkyne that forms a stable and fast-reacting cyclooctyne-alkyne cycloaddition reaction with azide-containing molecules.
In pharmaceutical research and development, DBCO-PEG-Maleimide, MW 5K has been used for the conjugation of drugs, peptides, and imaging agents to targeting biomolecules such as antibodies, proteins, and enzymes. This bioconjugation strategy allows for the specific delivery of therapeutic or imaging agents to diseased tissues or cells, reducing off-target effects and enhancing therapeutic efficacy. Additionally, DBCO-PEG-Maleimide, MW 5K has been used for the labeling of biomolecules with fluorescent dyes or biotin, allowing for the detection, quantification, and visualization of target molecules in biological samples.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
