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Maleimide-PEG-DBCO is a bioconjugation reagent that contains three distinct functional groups: a maleimide group, a polyethylene glycol (PEG) linker, and a dibenzocyclooctyne (DBCO) group. These functional groups enable the selective and efficient conjugation of Maleimide-PEG-DBCO to target biomolecules such as proteins, peptides, and antibodies, for a wide range of applications in pharmaceutical research and development.

The maleimide group, which is highly reactive towards thiol groups (-SH) on cysteine residues, allows for specific and irreversible binding to biomolecules. The PEG linker serves as a spacer, which provides increased solubility, reduced steric hindrance, and improved stability of the conjugates. Finally, the DBCO group enables rapid and efficient conjugation to azide groups (-N3) through a copper-free click chemistry reaction, which is an attractive alternative to traditional coupling methods.

Maleimide-PEG-DBCO is widely used for the synthesis of antibody-drug conjugates (ADCs), which are a promising class of therapeutics that combine the specificity of monoclonal antibodies with the cytotoxic effects of small-molecule drugs.


Cat# Name Structure M.W. Purity Pricing
AP15120DBCO-PEG-Mal, MW 1K1000≥95% Pricing
AP15271DBCO-PEG-Mal, MW 2K2000≥95% Pricing
AP15121DBCO-PEG-Mal, MW 5K5000≥95% Pricing

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