DBCO-NH-PEG12-Maleimide
DBCO-NH-PEG12-Maleimide is a high-purity heterobifunctional PEG linker with a DBCO group for copper-free strain-promoted alkyne–azide cycloaddition (SPAAC) and a maleimide for thiol-specific conjugation. The long PEG12 spacer enhances solubility, flexibility, and minimizes steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is especially suited for dual labeling, multifunctional bioconjugates, and targeted delivery systems.
Key Features and Benefits
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DBCO Group: Enables copper-free click chemistry with azides for bioorthogonal conjugation.
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Maleimide Group: Selectively reacts with thiol groups to form stable thioether bonds.
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PEG12 Spacer: Improves solubility, flexibility, and spatial separation of reactive groups.
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Heterobifunctional Design: Allows sequential and orthogonal bioconjugation.
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High Purity: Supplied at >95% purity for reproducible, high-yield results.
Applications
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Dual labeling and multifunctional conjugates.
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Antibody–drug conjugates (ADCs).
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Protein and peptide modification.
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Nanoparticle and surface functionalization.
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Targeted drug delivery and imaging probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve maleimide reactivity.
DBCO-NH-PEG12-Maleimide offers orthogonal SPAAC and thiol–maleimide reactivity with enhanced solubility and flexibility from its PEG12 spacer, making it ideal for multifunctional bioconjugation and targeted therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
