DBCO-Maleimide
This product is a heterobifunctional linker combining a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and a maleimide group for thiol-specific conjugation. This design specifically enables dual bioorthogonal and thiol reactivity, making it highly valuable for bioconjugation, ADC development, and multifunctional probe design.
Key Features and Benefits:
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DBCO Group: Performs rapid, catalyst-free SPAAC click chemistry with azides.
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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Dual Reactivity: Integrates orthogonal bioorthogonal and thiol-targeted chemistries.
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Compact Design: Offers efficient conjugation with minimal steric hindrance.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Antibody–Drug Conjugates (ADCs): Provides dual-reactive linkers for targeted drug delivery.
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Bioconjugation: Couples biomolecules via azide/alkyne and thiol handles.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Enables PEGylated scaffolds with dual functionality.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature maleimide hydrolysis.
This product integrates SPAAC click chemistry with thiol conjugation in one compact scaffold, specifically enabling versatile dual-functional conjugation for therapeutic and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
