DBCO-C2-PEG4-NH-Boc
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group, a short C2-PEG4 spacer, and a Boc-protected amine. The DBCO enables rapid, copper-free SPAAC click chemistry with azides. The Boc-protected amine remains stable during reactions and can be selectively deprotected specifically for further coupling to carboxyls or activated esters. The PEG4 spacer improves solubility and reduces steric hindrance, making this reagent especially well suited for multifunctional bioconjugation.
Key Features and Benefits
-
DBCO Group: Performs fast, copper-free SPAAC click chemistry with azides.
-
Boc-Protected Amine: Provides orthogonal reactivity; deprotects under mild acidic conditions.
-
PEG4 Spacer: Improves solubility and accessibility with moderate flexibility.
-
Dual Reactivity: Combines click chemistry with protected amine functionality.
-
High Purity: Produced to ≥95% purity for reproducibility.
Applications
-
Bioconjugation: Links azide-modified biomolecules with controlled amine coupling.
-
Protein and Antibody Labeling: Provides orthogonal modification strategies.
-
Probe Development: Builds multifunctional imaging and diagnostic tools.
-
Drug Delivery: Functions as a modular linker in therapeutic systems.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Remove Boc group under mild acidic conditions; prepare fresh solutions before use.
This product integrates bioorthogonal SPAAC chemistry with a protected amine handle in a PEG4 framework, specifically enabling flexible conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
