DBCO-Amido-PEG4-Amido-Maleimide
This high-purity PEG linker has a DBCO for copper-free SPAAC click chemistry and a maleimide for thiol coupling. The PEG4 spacer specifically improves solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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DBCO Group – Enables rapid, copper-free click chemistry with azides.
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Maleimide Group – Selectively reacts with thiols for stable conjugation.
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PEG4 Spacer – Improves solubility and accessibility while minimizing steric hindrance.
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Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable, reproducible results.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) synthesis
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Multifunctional imaging and diagnostic probe development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to maintain reactivity.
This product combines copper-free click chemistry via DBCO with thiol–maleimide conjugation, linked by PEG4 for solubility and flexibility, especially ideal for precise orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
