DLin-MC3-DMA is one of the most widely used cationic lipids, DLin-MC3-DMA (MC3), ALC-0315 and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapy. DLin-MC3-DMA can be combined with other lipids to form lipid nanoparticles (LNPs). Formulations containing DLin-MC3-DMA have been used to develop LNPs for siRNA delivery. Lipid nanoparticles (LNPs) containing distearoylphosphatidylcholine (DSPC) and ionizable aminolipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA ) are effective in vivo siRNA delivery vehicles.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.