D-Lin-MC3-DMA (MC3), fully known as (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate, is a potent synthetic ionizable lipid with a pKa of 6.44. It is commonly used in combination with other lipids to form lipid nanoparticles (LNPs) for the delivery of siRNA, mRNA, and DNA. MC3 is particularly effective due to its ability to become protonated at slightly acidic pH levels, facilitating the release of the RNA or DNA payload inside target cells.
Key Features:
- Ionizable Lipid: MC3 can change charge based on pH, making it highly effective for endosomal escape during intracellular delivery of nucleic acids.
- pKa of 6.44: This allows it to become ionized in the acidic environment of endosomes, helping to release the genetic material inside cells.
- Cationic at Acidic pH: Ensures effective interaction with nucleic acids and promotes membrane disruption for efficient delivery.
Applications:
- siRNA, mRNA, DNA Delivery: MC3 is a critical component in lipid nanoparticle formulations for delivering therapeutic nucleic acids such as siRNA and mRNA, widely used in mRNA vaccines and gene therapy.
- LNP Formulation: It is combined with other lipids to create stable lipid nanoparticles that protect nucleic acids in the bloodstream and deliver them to target cells.
- Endosomal Escape: MC3’s ionizable nature helps nucleic acids escape from endosomes, increasing the efficiency of intracellular delivery.
Benefits:
- Potent RNA Delivery: MC3 provides an efficient mechanism for delivering nucleic acids into cells, making it vital for RNA-based therapies.
- Research Grade: Available for research purposes, MC3 is commonly used in vaccine development, gene therapy, and biotechnology.
D-Lin-MC3-DMA is an essential lipid for forming LNPs used in cutting-edge research in genetic therapies and RNA delivery systems. Its role in helping nucleic acids escape endosomes makes it indispensable for applications requiring precise intracellular delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
