Cyclosporine A

Cyclosporine A is a cyclic peptide widely used in immunology, cell biology, and pharmacology research. It binds cyclophilin and inhibits calcineurin signaling which specifically suppresses NFAT activation and reduces transcription of interleukin-2 and other immune-response genes.

Key Features and Benefits

• Cyclic Peptide: Cyclosporine A is a cyclic undecapeptide with potent biological activity.
• Calcineurin Inhibitor: The cyclosporine-cyclophilin complex inhibits the phosphatase activity of calcineurin.
• NFAT Signaling: Calcineurin inhibition specifically reduces NFAT dephosphorylation and nuclear translocation.
• T-Cell Research: Commonly used to investigate T-cell activation and immune signaling pathways.
• IL-2 Regulation: Suppresses IL-2 transcription through inhibition of calcineurin-NFAT signaling.
• Research Standard: Widely studied in immunology, transplantation biology, pharmacology, and drug metabolism research.

Applications

• Immunology Research: Used to investigate immune activation and immunosuppressive mechanisms.
• T-Cell Signaling: Supports studies of T-cell receptor signaling and downstream cellular responses.
• Calcineurin-NFAT Research: Used to investigate calcineurin-dependent NFAT signaling pathways.
• Cytokine Research: Supports studies specifically involving IL-2 and other immune-related gene responses.
• Drug Metabolism Research: Used in pharmacokinetic, transporter, CYP3A, and drug-interaction studies.

Storage and Handling

• Storage: Store according to the product specification in a tightly sealed container. Protect from moisture, light, and excessive heat.
• Handling: Follow appropriate laboratory procedures and product-specific safety documentation.

Cyclosporine A is a well-characterized research compound for studying calcineurin-NFAT signaling and T-cell activation that also supports immunology, cytokine regulation, pharmacology, and drug metabolism research.