Cbz-N-Amido-PEG36-acid
This product is a long-chain PEG36 linker with a Cbz-protected amide and a terminal carboxylic acid. The extended PEG36 spacer provides excellent hydrophilicity, flexibility, and spacing, while the Cbz group offers stable carbamate protection for orthogonal conjugation strategies.
Key Features and Benefits:
-
Cbz-Protected Amide: Stable carbamate protection, removable under hydrogenolysis.
-
Carboxylic Acid Group: Couples with primary amines to form stable amide bonds.
-
PEG36 Spacer: Provides maximum solubility, flexibility, and reduced steric hindrance.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
-
Orthogonal Design: Supports stepwise, controlled, and multifunctional synthesis.
Applications:
-
Bioconjugation: Enables precise attachment of proteins, peptides, and biomolecules with long PEG spacing.
-
Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
-
Surface Modification: Functionalizes nanoparticles, hydrogels, and polymers.
-
Material Science: Incorporates into PEGylated scaffolds for advanced material systems.
Storage and Handling:
-
Storage: Store at –20 °C in a dry, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid integrity.
This product provides long-chain PEG spacing with dual functionality, making it an especially versatile reagent for advanced synthesis, drug delivery, and surface engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.