Cbz-N-Amido-PEG3-acid
This product is a short PEG3 linker with a Cbz-protected amide and a terminal carboxylic acid. The PEG3 spacer provides solubility and flexibility, while the Cbz group offers stable carbamate protection for orthogonal conjugation strategies.
Key Features and Benefits:
-
Cbz-Protected Amide: Stable carbamate group, removable by hydrogenolysis.
-
Carboxylic Acid Group: Couples efficiently with amines to form amide bonds.
-
PEG3 Spacer: Enhances solubility and reduces steric hindrance in conjugation.
-
High Purity: Ensures reproducibility in bioconjugation and synthesis workflows.
-
Orthogonal Reactivity: Supports selective and stepwise synthetic strategies.
Applications:
-
Bioconjugation: Link proteins, peptides, and biomolecules with compact PEG spacing.
-
Drug Delivery: Improves solubility and pharmacokinetics of therapeutic payloads.
-
Surface Functionalization: Modify nanoparticles, hydrogels, or polymers.
-
Synthetic Chemistry: Intermediate for PEGylated scaffolds and materials.
Storage and Handling:
-
Storage: Store at –20 °C in a dry, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid stability.
This product provides short PEG spacing with stable Cbz protection and a carboxyl group, making it an especially versatile reagent for orthogonal conjugation and advanced synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
