Cbz-N-Amido-PEG10-acid
This product is a PEG10 linker with a Cbz-protected amide and a terminal carboxylic acid. The PEG10 spacer provides hydrophilicity, flexibility, and medium-to-long spacing, while the Cbz group offers stable carbamate protection for controlled and orthogonal conjugation strategies.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate protecting group, removable by hydrogenolysis.
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Carboxylic Acid Group: Couples efficiently with amines to form stable amide bonds.
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PEG10 Spacer: Balances solubility, flexibility, and steric accessibility.
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High Purity: Ensures reproducibility in sensitive workflows.
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Orthogonal Reactivity: Supports multistep and selective conjugation designs.
Applications:
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Bioconjugation: Facilitates precise biomolecule modification with orthogonal protection.
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Drug Delivery: PEGylated linker enhances solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biomaterials.
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Synthetic Chemistry: Useful intermediate for protected PEGylated scaffold design.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain Cbz and acid stability.
This product provides medium-length PEG spacing with stable protection, making it an especially versatile tool for orthogonal synthesis, drug delivery, and advanced material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
