Bromoacetamide-PEG3-acetic acid
Bromoacetamide-PEG3-acetic acid is a high-purity heterobifunctional PEG linker with a bromoacetamide group for thiol-specific alkylation and a terminal carboxylic acid for amide bond formation. The PEG3 spacer enhances solubility, improves flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is especially useful for preparing multifunctional biomolecules, drug conjugates, and surface modifications where thiol coupling and further derivatization are required.
Key Features and Benefits
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Bromoacetamide Group: Selectively reacts with thiols to form stable thioether bonds.
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Carboxylic Acid: Compatible with standard carbodiimide or active ester coupling for further functionalization.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Enables orthogonal, stepwise conjugation strategies.
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High Purity: Supplied at >95% purity for consistent and reproducible results.
Applications
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Stepwise Bioconjugation: Sequentially attach thiol-containing and amine-containing molecules.
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Protein and Peptide Modification: Site-specific thiol labeling with additional functionalization options.
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Nanoparticle Functionalization: Introduce thiol-reactive handles to surfaces.
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Drug Delivery Systems: Create stable, targeted linkers for controlled payload release.
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Diagnostic Probes: Develop multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
Bromoacetamide-PEG3-acetic acid combines thiol reactivity with a carboxylic acid handle in a hydrophilic PEG3 framework, offering versatility for orthogonal, stepwise bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
