Boc-aminooxy NHS acetate
This product is a heterobifunctional linker containing a Boc-protected aminooxy group and an NHS ester. It enables oxime ligation and amine coupling, specifically offering orthogonal functionality and controlled reactivity for bioconjugation and synthesis.
Key Features and Benefits
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Boc-Protected Aminooxy: Allows selective deprotection for oxime ligation with aldehydes or ketones.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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Orthogonal Design: Combines protected aminooxy reactivity with amine conjugation.
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Compact Scaffold: Minimizes steric hindrance while maintaining solubility.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links carbonyl- and amine-containing biomolecules with orthogonal chemistry.
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Probe Development: Builds multifunctional probes for diagnostics and chemical biology.
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Drug Delivery: Provides scaffolds with protected and active reactive groups.
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Organic Synthesis: Serves as an intermediate in modular linker chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Boc cleavage.
This product integrates protected aminooxy chemistry with amine-reactive NHS ester, specifically offering solubility and orthogonal reactivity in a compact scaffold.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
