Boc-HyNic-PEG2-Propargyl
This product is a multifunctional PEG2 linker featuring a Boc-protected hydrazinonicotinamide (HyNic) group and a terminal propargyl (alkyne). The PEG2 spacer provides compact hydrophilicity and flexibility, while the Boc-protected HyNic enables selective deprotection and hydrazone formation, and the alkyne supports bioorthogonal click chemistry with azides.
Key Features and Benefits:
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Boc-Protected HyNic: Acid-labile protecting group for controlled hydrazone chemistry with aldehydes/ketones.
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azide partners.
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PEG2 Spacer: Provides solubility and flexibility with minimal steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Supports orthogonal conjugation and multistep synthetic strategies.
Applications:
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Bioconjugation: Combines aldehyde/ketone coupling with click chemistry.
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Click Chemistry: Azide–alkyne ligation for bioorthogonal labeling.
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Drug Delivery: PEGylated linker enhances solubility and controlled conjugation.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and alkyne stability.
This product provides dual functionality with a protected HyNic group and a click-ready alkyne, making it an especially powerful tool for orthogonal conjugation and advanced bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.