Boc-HyNic-PEG2-Azide
This product is a heterobifunctional PEG2 linker containing a Boc-protected HyNic group and a terminal azide. The HyNic moiety enables hydrazone bond formation after deprotection, while the azide allows click chemistry with alkynes, making it a versatile tool for orthogonal conjugation.
Key Features and Benefits:
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Boc-Protected HyNic: Provides stability and controlled deprotection for hydrazone coupling.
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkyne-functional molecules.
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PEG2 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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High Purity: Suitable for sensitive and reproducible workflows.
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Orthogonal Design: Supports stepwise and multifunctional conjugation.
Applications:
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Bioconjugation: Combine hydrazone chemistry with click reactions for complex constructs.
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Drug Delivery: Useful in linker-payload designs for targeted therapeutics.
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Surface Functionalization: Attach dual functionalities to nanoparticles, hydrogels, or polymers.
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Synthetic Chemistry: Serves as a versatile intermediate for orthogonal synthesis.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain reactivity and stability.
This product combines Boc-protected hydrazone chemistry with click-enabled azide reactivity, making it an especially powerful linker for multifunctional and orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
