Boc-HyNic-PEG2-Amino-DBCO
This product is a PEG linker with a Boc-protected HyNic, PEG2 spacer, amine, and DBCO. The HyNic enables hydrazone coupling after deprotection, while the DBCO supports copper-free click chemistry. The PEG2 chain specifically improves solubility and reduces steric hindrance.
Key Features and Benefits
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Boc-Protected HyNic: Offers controlled activation for hydrazone conjugation with aldehydes or ketones.
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DBCO Group: Enables fast, copper-free SPAAC reactions with azides.
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PEG2 Spacer: Enhances solubility and minimizes steric hindrance in conjugation workflows.
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Dual Reactivity: Combines hydrazone ligation and click chemistry for multifunctional applications.
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High Purity: Produced to ≥95% purity for reliable and reproducible results.
Applications
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Bioconjugation: Couples aldehyde/ketone-functionalized biomolecules with azide-modified partners.
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Probe Development: Builds multifunctional probes for imaging, diagnostics, and target identification.
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Drug Delivery: Serves as a versatile linker for PEGylated therapeutics and ADC design.
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Chemical Biology: Enables orthogonal dual-labeling strategies in complex systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Deprotect Boc under standard acidic conditions before hydrazone coupling; prepare fresh solutions before use.
This product integrates Boc-protected hydrazone chemistry with copper-free DBCO click functionality, specifically providing a versatile tool for dual-reactive conjugation strategies in bioconjugation and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
