Bromo-PEG3-bromide (CAS Number: 31255-26-2) is a polyethylene glycol (PEG) derivative featuring bromide groups at both ends. These bromide groups are excellent leaving groups in nucleophilic substitution reactions, facilitating the incorporation of PEG spacers into various molecules. The hydrophilic PEG3 spacer enhances solubility in aqueous media, making it valuable in pharmaceutical research and development.
Chemical Properties:
- Chemical Formula: C₈H₁₆Br₂O₃
- Molecular Weight: 320.02 g/mol
- Physical State: Colorless to light yellow liquid
- Purity: Typically ≥95%
Applications:
- Bioconjugation and Crosslinking: The bifunctional bromide groups enable efficient nucleophilic substitution reactions, allowing for the attachment of PEG chains to biomolecules, which can improve their solubility and stability.
- PROTAC Synthesis: Serves as a linker in the creation of Proteolysis Targeting Chimeras (PROTACs), aiding in targeted protein degradation for therapeutic applications.
- Nanoparticle and Surface Modification: Employed in modifying nanoparticles and surfaces to enhance biocompatibility and functionality, which is crucial in drug delivery systems and diagnostic tools.
Storage and Handling:
- Storage Conditions: Store at -20°C to maintain stability.
- Safety Measures: Handle with appropriate protective equipment; refer to the Safety Data Sheet (SDS) for detailed information.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
