Bis-sulfone-PEG12-Acid contains two sulfone functional groups (-SO2-) and an acid group (-COOH) attached to a PEG chain of 12 repeating units.
Bis-sulfone-PEG12-Acid has been widely utilized in the development of innovative drug delivery systems. Its sulfone groups allow for the formation of stable crosslinked networks when exposed to mild oxidizing agents, such as hydrogen peroxide or sodium periodate. The resulting hydrogels exhibit excellent biocompatibility, low toxicity, and controlled drug release properties, making them suitable for various biomedical applications.
The acid group in Bis-sulfone-PEG12-Acid offers additional functionality for conjugation with therapeutic agents, such as proteins, peptides, or small molecules. The acid group can be activated by coupling agents, such as carbodiimides, to form stable amide bonds with the amino groups of the therapeutic agents. The resulting conjugates exhibit improved stability, increased solubility, and enhanced therapeutic efficacy in vivo.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.