Bis-sulfone Acid (CAS: 124243-00-1) is a bis-alkylating reagent designed for selective and controlled bioconjugation. It specifically targets cysteine residues in proteins, enabling the rebridging of reduced disulfide bonds, which is particularly useful in the development of antibody-drug conjugates (ADCs).
Key Features:
- Selective Cysteine Targeting: Bis-sulfone Acid reacts with thiol groups from reduced disulfide bonds, facilitating site-specific conjugation.
- Disulfide Rebridging: Allows for the covalent reformation of disulfide bonds, maintaining protein structural integrity.
- Versatile Functionalization: The carboxylic acid group enables further chemical modifications, such as amide bond formation.
Applications:
- Antibody-Drug Conjugates (ADCs): Facilitates the attachment of cytotoxic agents to antibodies through stable linkages.
- Protein Labeling: Enables site-specific labeling of proteins for research and therapeutic purposes.
- Bioconjugation: Useful in linking biomolecules while preserving their native structures.
Handling and Storage:
- Solubility: Soluble in organic solvents like DMSO, DMF, DCM, THF, and chloroform.
- Appearance: White crystalline solid.
- Storage Conditions: Store at -20°C in a desiccated environment to maintain stability.
Bis-sulfone Acid is a valuable tool in bioconjugation strategies, offering specificity and stability in the modification of proteins and other biomolecules.
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