Bis-PEG9-acid (CAS 1268488-70-5) is a polyethylene glycol (PEG) derivative with two terminal carboxylic acid groups. The hydrophilic PEG spacer enhances solubility in aqueous media, while the carboxylic acids can react with primary amines in the presence of activators (e.g., EDC or HATU) to form stable amide bonds.
Key Features:
- Molecular Formula: C₂₂H₄₂O₁₃
- Molecular Weight: 514.56 g/mol
- Structure: HOOC-(CH₂CH₂O)₉-CH₂CH₂-COOH
- Solubility: Highly soluble in water and common organic solvents
Applications:
- Bioconjugation:
- Facilitates the attachment of biomolecules through amide bond formation.
- Drug Delivery:
- Improves solubility and pharmacokinetics of therapeutic agents.
- Hydrogel Formation:
- Crosslinks with polymers to create hydrogels for drug delivery and tissue engineering.
- PROTAC Synthesis:
- Serves as a linker in the development of proteolysis-targeting chimeras.
Bis-PEG9-acid is a versatile tool in chemical biology, aiding in the development of advanced therapeutics and biomaterials.
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