Bis-PEG25-acid (CAS 51178-68-8) is a polyethylene glycol (PEG) derivative featuring two terminal carboxylic acid groups. The PEG spacer enhances solubility in aqueous media, while the carboxylic acids can react with primary amines in the presence of activators (e.g., EDC or DCC) to form stable amide bonds.
Key Features:
- Molecular Formula: C₅₄H₁₀₆O₂₉
- Molecular Weight: 1219.4 g/mol
- Solubility: Highly soluble in water
- Functional Groups: Two terminal carboxylic acids
Applications:
- Bioconjugation: Facilitates the attachment of biomolecules through amide bond formation.
- Drug Delivery: Improves solubility and pharmacokinetics of therapeutic agents.
- Hydrogel Formation: Crosslinks with polymers to create hydrogels for drug delivery and tissue engineering.
- PROTAC Synthesis: Serves as a linker in the development of proteolysis-targeting chimeras.
Bis-PEG25-acid is a versatile tool in chemical biology, aiding in the development of advanced therapeutics and biomaterials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
