Bis-Mal-Lysine-PEG4-TFP ester
Bis-Mal-Lysine-PEG4-TFP ester is a multifunctional crosslinker specifically with two maleimides, a lysine core, a PEG4 spacer, and a TFP ester. It enables thiol and amine conjugation with improved solubility and flexibility, especially ideal for protein crosslinking, ADCs, and probe design.
Key Features and Benefits
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Bis-Maleimide Groups: Enable dual thiol conjugation, forming stable thioether linkages.
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TFP Ester: Highly reactive toward primary amines for efficient, stable amide bond formation.
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Lysine Core: Provides a branching point for multifunctional attachment.
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PEG4 Spacer: Enhances solubility and accessibility in bioconjugation workflows.
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High Purity: Produced to ≥95% purity for reliable and reproducible performance.
Applications
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Protein Crosslinking: Bridges thiol- and amine-containing biomolecules for stable conjugates.
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Antibody–Drug Conjugates (ADCs): Serves as a cleavable linker scaffold for drug delivery.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Bioconjugation: Supports orthogonal conjugation strategies in complex biological systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Dissolve freshly in dry solvent; avoid repeated freeze–thaw cycles.
This product integrates thiol- and amine-reactive chemistry with a PEG4 solubilizing spacer, making it an especially powerful tool for multifunctional bioconjugation and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
