Bis-Mal-Lysine-PEG4-acid (CAS: 1426164-52-4) is a bifunctional PEG linker featuring two maleimide groups and a terminal carboxylic acid. The maleimide groups react specifically with thiol-containing molecules, forming stable thioether bonds, while the carboxylic acid can form amide bonds with primary amines. The PEG4 spacer improves water solubility, making it suitable for various bioconjugation and drug delivery applications.
Key Features:
- Functional Groups: Two maleimide groups for thiol coupling and a terminal carboxylic acid for amine conjugation.
- Molecular Formula: C₃₁H₄₅N₅O₁₃
- Molecular Weight: 695.71 g/mol
- Purity: Typically ≥95%
Applications:
- Antibody-Drug Conjugates (ADCs): Acts as a linker for attaching therapeutic agents to antibodies for targeted delivery.
- Bioconjugation: Enables stable biomolecule conjugation through thiol-maleimide and amide bond formation.
- Protein Labeling: Facilitates protein modification and tagging using thiol-reactive chemistry.
- PEGylation: Enhances solubility, stability, and bioavailability of conjugated compounds.
This linker is ideal for applications requiring precise and stable molecular assembly, making it valuable in biopharmaceutical development and molecular diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
