Bis-BCN-PEG1-diamide
This product is a homobifunctional PEG linker containing two bicyclo[6.1.0]nonyne (BCN) groups connected by a PEG1 diamide spacer. It specifically enables copper-free click chemistry with azides, offering compact, soluble, and highly reactive functionality for bioconjugation and materials science.
Key Features and Benefits
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Dual BCN Groups: React rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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PEG1 Diamide Spacer: Provides compact spacing, solubility, and biocompatibility.
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Homobifunctional Design: Enables symmetric crosslinking of azide-modified molecules.
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Copper-Free Chemistry: Suitable for live-cell and biological applications.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Crosslinks azide-modified proteins, peptides, or biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with dual bioorthogonal handles.
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Material Science: Functionalizes polymers, nanoparticles, and hydrogels with click-ready groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates dual BCN click handles with a PEG1 diamide spacer, specifically offering compact and efficient crosslinking for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
