Biotin-Poly(L-Glutamic Acid), MW 5K is a biotin-functionalized, carboxyl-rich poly(amino acid) based on poly(L-glutamic acid). It combines a polyanionic polymer chain with biotin functionality specifically for avidin recognition, bioconjugation, and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) specifically provides a biodegradable polymer framework with multiple pendant carboxyl groups.
- MW 5K: Provides a lower molecular weight poly(L-glutamic acid) chain with multiple glutamic acid residues and carboxyl functionality.
- Biotin Functionality: Provides high-affinity noncovalent recognition by avidin and streptavidin proteins.
- Avidin-Streptavidin Recognition: Biotin enables specific binding to compatible avidin- and streptavidin-based systems.
- Carboxyl-Rich Structure: Pendant carboxyl groups specifically provide additional sites for chemical modification and conjugation.
- Polyanionic Character: Deprotonated carboxyl groups specifically provide negative charge under suitable pH conditions.
- Multifunctional Polymer Platform: Combines biotin recognition with the carboxyl-rich properties of poly(L-glutamic acid).
- Bioconjugation Platform: Supports development of biotin-containing polymer conjugates and affinity-based research systems.
Applications
- Biotin-Avidin Binding: Supports high-affinity interactions with compatible avidin and streptavidin proteins.
- Bioconjugation: Enables development of biotin-functionalized polymer conjugates for affinity-based research applications.
- Polymer Functionalization: Pendant carboxyl groups provide additional sites for introducing compatible functional molecules.
- Nanoparticle Functionalization: Supports development of biotin-functionalized polymeric and nanoparticle systems.
- Surface Modification: Enables preparation of functional polymer coatings and surfaces for avidin- or streptavidin-based studies.
- Affinity-Based Research: Supports capture, immobilization, labeling, and recognition strategies using biotin-avidin interactions.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Biotin-Poly(L-Glutamic Acid), MW 5K combines a carboxyl-rich poly(amino acid) chain with biotin functionality and specifically supports avidin-streptavidin recognition, bioconjugation, polymer functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.