Biotin-Poly(L-Glutamic Acid), MW 2.5K (also Biotin-pGlu, MW 2,500)
- Structure: A negatively charged synthetic polyamino acid composed of L-glutamic acid units linked by γ-peptide bonds, with a terminal biotin group and one carboxyl (COOH) per glutamic acid unit.
- Key Properties: White/off-white crystalline solid; soluble in water (especially alkaline), dichloroacetic acid, chloroform, warm DMF, and dioxane.
- Core Function: The biotin moiety enables high-affinity binding to avidin/streptavidin (Kd ≈ 10⁻¹⁵ M), serving for protein conjugation, molecular labeling, and targeted delivery.
- Applications: Drug delivery, immunodetection (Western blot, IP), biosensors, and layer-by-layer surface coating.
- Storage: Store at −20°C.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.