BCN-PEG1-Val-Cit-PAB-PNP is a cleavable linker commonly used in antibody-drug conjugates (ADCs) for targeted drug delivery.
Key Features:
- BCN Group: Enables copper-free click chemistry with azide-containing molecules.
- PEG1 Spacer: Increases solubility and flexibility, reducing steric hindrance.
- Val-Cit Dipeptide: Cleavable by cathepsin B, allowing controlled drug release within target cells.
- PAB Spacer: Ensures effective drug release after cleavage of the Val-Cit linker.
- PNP Group: Acts as a leaving group, facilitating conjugation with amine-containing payloads.
Applications:
- Antibody-Drug Conjugates (ADCs): Links antibodies to cytotoxic drugs, enabling targeted delivery to cancer cells.
- Bioconjugation: Connects various biomolecules for research and therapeutic applications.
Storage and Handling:
- Storage: Store at -20°C in a dry, dark place.
- Handling: Handle in an inert atmosphere to ensure stability.
BCN-PEG-Val-Cit-PAB-PNP is an essential tool in targeted drug delivery, enabling enzyme-triggered therapeutic release in specific cells, especially for cancer therapies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
