Azidobutyric Acid NHS Ester
This product is a high-purity heterobifunctional linker with an azide for copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC) click chemistry, and an N-hydroxysuccinimide (NHS) ester specifically for rapid, selective coupling with primary amines to form stable amide bonds. Its compact structure ensures minimal steric hindrance, making it especially ideal for efficient, orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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Azide Group – Enables CuAAC or SPAAC click chemistry for stable, selective linkages.
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NHS Ester – Reacts efficiently with primary amines under mild conditions.
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Compact Linker Design – Minimizes steric hindrance for optimal reaction efficiency.
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Orthogonal Reactivity – Allows dual functionalization without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible results.
Applications
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Protein and peptide modification
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Dual-labeling strategies for imaging or tracking
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Small molecule or drug conjugation
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Surface functionalization for biosensors and materials science
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Development of multifunctional probes and diagnostic tools
Storage and Handling
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents such as DMSO or DMF. Avoid prolonged exposure to moisture. Perform reactions under inert atmosphere when possible.
This product is a versatile, high-purity linker that combines an azide for click chemistry with an NHS ester for amine coupling, offering orthogonal reactivity for especially efficient bioconjugation in diverse applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
