Azido-aliphatic-NHS ester

Azido-aliphatic-NHS ester is a chemical compound used in pharmaceutical research and development as a functional group for labeling, cross-linking, and protein conjugation. The compound contains an azide functional group, which is highly reactive and can be easily clicked onto alkyne or alkenyl groups to form triazole linkages. This reaction is widely used in bioconjugation chemistry, which enables the creation of drug conjugates, imaging probes, and other biomedical tools. The NHS ester group in azido-aliphatic-NHS ester is also important as it enables the formation of stable amide bonds with primary amines on proteins or peptides. The introduction of these functional groups allows for the modification of biomolecules, making them more specific, potent, and bioavailable, thus advancing drug discovery and development.