Azido-PEG9-t-butyl ester
Azido-PEG9-t-butyl ester is a high-purity PEG linker with an azide specifically for click chemistry and a t-butyl ester as an acid-labile carboxylic acid protecting group. Its PEG9 spacer enhances solubility, reduces steric hindrance, and enables efficient conjugation for applications such as targeted therapeutics and imaging probes.
Key Features and Benefits:
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Azide Functional Group: Enables copper-catalyzed (CuAAC) or copper-free (SPAAC) click chemistry with alkyne-containing molecules.
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t-Butyl Ester Protection: Maintains carboxylic acid integrity during synthetic steps; removable under mild acidic conditions.
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PEG9 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation strategies for complex molecule assembly.
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High Purity: Supplied at >95% purity for consistent and reproducible performance.
Applications:
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Bioconjugation: Attach biomolecules, dyes, or drugs using orthogonal click chemistry and protected acid strategies.
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Drug Delivery Systems: Link targeting ligands and therapeutic agents through stable PEG chains.
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Surface Modification: Functionalize nanoparticles, polymers, or hydrogels with bioorthogonal handles.
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Multistep Organic Synthesis: Incorporate into synthetic pathways requiring acid-labile protection.
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Diagnostic Probe Development: Build multifunctional imaging agents for in vitro or in vivo applications.
Storage and Handling:
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Storage: Store at -20°C, in a dry, dark environment.
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Handling: Use dry solvents (DMSO or DMF) and avoid moisture to maintain azide and t-butyl ester stability.
Azido-PEG9-t-butyl ester delivers orthogonal reactivity and high solubility, making it an especially powerful tool for advanced bioconjugation, click chemistry workflows, and multifunctional probe synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
