Azido-PEG8-t-butyl ester
This product is a high-purity PEG reagent with an azide group for copper-catalyzed or strain-promoted alkyne–azide cycloaddition (CuAAC or SPAAC) and a tert-butyl ester–protected carboxyl for selective deprotection under mild acidic conditions. The PEG8 spacer improves solubility, flexibility, and reduces steric hindrance, enabling especially efficient conjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Compatible with CuAAC and SPAAC click chemistry for bioorthogonal labeling.
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t-Butyl Ester Protection – Acid-labile protection allows orthogonal functionalization strategies.
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PEG8 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Enables sequential modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent performance.
Applications
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Bioorthogonal labeling and click chemistry
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Protein, peptide, and small molecule modification
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Drug delivery linker design
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Multifunctional probe and nanoparticle functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines azide click chemistry with a t-butyl–protected carboxyl, separated by a PEG8 spacer for solubility and flexibility, enabling orthogonal conjugation strategies specifically in diverse bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
