Azido-PEG8-CH2CO2-PFP
This product is a heterobifunctional PEG8 linker featuring a terminal azide for click chemistry and a pentafluorophenyl (PFP) ester for efficient amine coupling. The PEG8 spacer specifically provides hydrophilicity, flexibility, and reduced steric hindrance, making it highly useful for orthogonal bioconjugation and drug delivery applications.
Key Features and Benefits:
-
Azide Group: Supports CuAAC and SPAAC click chemistry with alkynes.
-
PFP Ester: Reacts efficiently with primary amines under mild conditions.
-
PEG8 Spacer: Offers solubility, flexibility, and moderate chain length for spacing.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
-
Orthogonal Design: Enables multifunctional and stepwise conjugation.
Applications:
-
Bioconjugation: Dual-functional linker for proteins, peptides, and small molecules.
-
Click Chemistry: Azide–alkyne ligation for bioorthogonal labeling.
-
Drug Delivery: Facilitates linker–payload assembly for targeted therapeutics.
-
Surface Functionalization: Functionalizes nanoparticles, hydrogels, or biosensors.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve PFP ester and azide stability.
This product provides both azide and activated ester reactivity in a mid-length PEG spacer, making it an especially excellent reagent for orthogonal conjugation and advanced drug delivery design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
