Azido-PEG6-acid
Azido-PEG6-acid is a high-purity heterobifunctional PEG linker containing a terminal azide group and a carboxylic acid, connected by a PEG6 spacer. The azide moiety enables bioorthogonal conjugation through copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC), while the carboxylic acid allows further coupling to amines via amide bond formation. The PEG6 chain enhances hydrophilicity, solubility, and flexibility, making it especially suitable for applications in aqueous and organic systems.
Key Features
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Heterobifunctional PEG linker with azide and carboxylic acid termini
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Compatible with CuAAC and SPAAC click chemistry
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Carboxylic acid readily conjugates with amines via EDC/NHS chemistry
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PEG6 spacer improves solubility, hydrophilicity, and reduces steric hindrance
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High chemical purity for reproducible performance
Applications
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Bioconjugation and click chemistry workflows
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Antibody–drug conjugate (ADC) synthesis
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Surface and nanoparticle functionalization
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Polymer–drug or polymer–biomolecule conjugates
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Allow to equilibrate to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product combines an azide group for click chemistry with a reactive carboxylic acid, linked by a PEG6 chain specifically for solubility and flexibility in diverse bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
