Azido-PEG3-Val-Cit-PAB-PNP
This product is a multifunctional cleavable linker with an azide, PEG3 spacer, Val-Cit dipeptide, PAB spacer, and PNP ester. It enables bioorthogonal click chemistry, enzymatic cleavage, and amide coupling, making it especially useful in drug delivery and ADC design.
Key Features and Benefits
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Azide Group: Reacts with alkynes in CuAAC or SPAAC click chemistry.
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Val-Cit Dipeptide: Cleaved by cathepsin B, enabling intracellular payload release.
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PAB Spacer: Self-immolative unit ensuring efficient payload liberation.
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PNP Ester: Activated leaving group for coupling with amines or hydroxyls.
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PEG3 Spacer: Enhances solubility while maintaining compact flexibility.
Applications
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Antibody–Drug Conjugates (ADCs): Provides enzymatically cleavable linkers with orthogonal handles.
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Bioconjugation: Couples biomolecules via click chemistry and PNP ester reactivity.
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Drug Delivery: Ensures targeted intracellular release through cathepsin B cleavage.
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Probe Development: Builds multifunctional probes for imaging and mechanistic studies.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates click chemistry, enzymatic cleavage, and amide coupling in a PEG3 scaffold, making it an especially versatile tool for ADCs and multifunctional conjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
