Azido-PEG3-PFP ester
Azido-PEG3-PFP ester is a high-purity heterobifunctional PEG linker featuring an azide group for copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC) click chemistry, and a pentafluorophenyl (PFP) ester for rapid, efficient amine coupling. The PEG3 spacer improves hydrophilicity, enhances solubility, and minimizes steric hindrance, enabling especially high-yield conjugation in both aqueous and organic systems.
Key Features
-
Terminal azide group for bioorthogonal click chemistry (CuAAC or SPAAC)
-
PFP ester for fast, efficient reaction with primary amines
-
PEG3 spacer increases flexibility, solubility, and reduces aggregation
-
High chemical stability and purity
-
Compatible with both aqueous and organic solvents
Applications
-
Dual-functional bioconjugation strategies
-
Protein, peptide, and antibody modification
-
Nanoparticle and surface functionalization
-
Drug delivery, imaging, and diagnostic probe development
Storage and Handling
-
Store at –20 °C, protected from light and moisture
-
Bring to room temperature before opening
-
Avoid repeated freeze–thaw cycles
This product combines an azide for click chemistry with a PFP ester for rapid amine coupling, linked by a PEG3 spacer specifically for enhanced solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
