Azido-PEG12-t-butyl ester
This product is a high-purity PEG linker with an azide for copper-catalyzed or strain-promoted alkyne–azide cycloaddition (CuAAC or SPAAC) click chemistry and a tert-butyl ester–protected carboxyl group for selective deprotection under mild acidic conditions. The PEG12 spacer enhances solubility, flexibility, and reduces steric hindrance, specifically enabling efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Compatible with CuAAC and SPAAC click chemistry for bioorthogonal labeling.
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t-Butyl Ester Protection – Acid-labile protection enables orthogonal functionalization strategies.
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PEG12 Spacer – Improves solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible results.
Applications
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Bioorthogonal labeling and click chemistry
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Protein, peptide, and small molecule modification
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Drug delivery linker design
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Multifunctional probe and nanoparticle functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines azide click chemistry with a t-butyl–protected carboxyl, separated by a PEG12 spacer for solubility and flexibility, enabling efficient, orthogonal conjugation specifically in bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
