APN-C3-amine
APN-C3-amine is a high-purity PEG linker with an aminopyridyl nitrile (APN) group for specialized conjugation chemistry and a terminal primary amine for coupling to carboxylic acids or NHS esters. The short C3 alkyl spacer provides a compact, flexible bridge while maintaining high reactivity and minimal steric hindrance, making it suitable for precision bioconjugation in drug delivery, diagnostics, and advanced material applications.
Key Features and Benefits
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APN Functional Group: Enables selective conjugation or labeling strategies in specialized workflows.
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Primary Amine: Couples efficiently to carboxylic acids or activated esters.
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C3 Spacer: Offers a compact, flexible link with minimal steric interference.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
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Versatile Reactivity: Suitable for aqueous and organic bioconjugation systems.
Applications
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Protein and Peptide Modification: Introduce APN groups while coupling to amine-reactive partners.
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Drug Delivery Systems: Incorporate as a functional linker for targeted delivery.
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Nanoparticle Functionalization: Add APN handles for advanced surface chemistry.
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Diagnostic Probe Development: Build imaging and sensing agents with specialized reactivity.
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Material Science: Functionalize polymers and biomaterials with unique APN chemistry.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
APN-C3-amine provides APN reactivity and a primary amine in a short, flexible C3 spacer, enabling targeted, efficient bioconjugation for therapeutic, diagnostic, and material science applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
