Aminooxy-PEG2-azide linker contains an aminooxy group and an azide group. The PEG spacer increases the aqueous solubility of the resulting compound. The aminooxy has been used to conjugate with carbonyl bearing (ketone and aldehyde) biomolecules to form oxime for reversible linkage spacer.Oxime ligation is one of the hot topics in the field of bioconjugation of molecules due to its chemoselectivity and hydrolytic stability. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.