Amino-PEG2-acid, CAS 791028-27-8, is a bifunctional PEG linker with an amino group on one end and a carboxylic acid on the other. The PEG2 spacer boosts water solubility. The amino group reacts with carboxylic acids, NHS esters, or carbonyls, while the carboxylic acid forms stable bonds with amines, especially with EDC or HATU.
Key Features
- Dual Functional Groups: The amino group reacts efficiently with carboxylic acids, NHS esters, or carbonyls, while the carboxylic acid forms bonds with primary and secondary amines.
- Improved Solubility: The PEG spacer boosts water solubility, thereby reducing aggregation and improving reaction efficiency.
- Versatile Reactivity: It is suitable for various methods, including amide coupling and reductive amination.
Applications
- Bioconjugation: It links proteins, peptides, or other biomolecules to form stable amide bonds, which are ideal for research, diagnostics, or therapeutic use.
- Drug Development: The linker acts as a key component for PEGylated drugs or prodrugs, thus increasing stability and solubility.
- Surface Modification: It adds reactive groups to surfaces, enhancing biocompatibility and preparing them for further conjugation.
Amino-PEG2-acid offers both flexibility and efficiency. It works exceptionally well in bioconjugation, drug development, and surface modification, ensuring strong performance across various applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
