This high‑molecular‑weight amine‑terminated poly(ε‑caprolactone) possesses elongated aliphatic chains, intensified intermolecular entanglement and elevated crystallinity relative to 2K, 3K and 5K lower‑molecular‑weight grades. Its terminal primary amine group can readily form stable amide linkages with carboxyl‑modified proteins, peptides and targeting ligands via EDC/NHS activation. Extended polymer chains markedly retard hydrolytic degradation and improve mechanical resilience of nanoparticles and electrospun constructs. This polymer supports weeks‑to‑month‑scale in vitro and pre‑clinical in‑vivo evaluation, delivering superior colloidal stability for long‑persistent nanocarriers, yet avoids the multi‑month ultra‑slow degradation exhibited by 15K and 20K ultra‑high‑MW PCL‑Amine materials.
Key Features: ‑ Long‑chain high‑crystallinity PCL backbone functionalized with terminal primary amine moiety, engineered for mechanically robust cationic nanoparticle and scaffold fabrication ‑ Significantly retarded hydrolytic erosion rate, enabling weeks‑to‑month‑level structural retention for long‑duration in‑vitro and in‑vivo experimental workflows ‑ Strong chain entanglement suppresses nanoparticle disassembly and premature payload leakage under complex biological media environments ‑ Endows nanoparticles with tunable positive surface potential, supporting adjustable cell‑particle interaction and cellular‑uptake behaviours ‑ Spectroscopically validated amine end‑group fidelity; low residual monomer and catalyst levels suitable for advanced cell assays and small‑animal pre‑clinical assessment
Applications: ‑ Fabrication of amine‑functionalized long‑persistent nanoparticles and micelles for sustained drug release and prolonged biodistribution profiling following EDC/NHS‑mediated ligand immobilization ‑ EDC/NHS‑driven surface bio‑functionalization of electrospun scaffolds for mid‑long‑term tissue‑engineering research without strict implant‑grade durability requirements ‑ Preparation of amide‑bonded polymer‑protein and polymer‑peptide conjugates for long‑acting targeted delivery in small‑animal models ‑ Development of cationic functional coatings for biosensors requiring extended stability under biological conditions ‑ Pre‑clinical formulation validation of long‑lived particulate carriers serving as transitional material toward ultra‑high‑MW implant‑oriented PCL‑Amine platforms
Handling & Storage: Store lyophilized polymer powder at −20 °C under dry inert‑gas atmosphere. Terminal primary amine groups are prone to react with ambient carbon dioxide to form carbamate impurities, which reduce bioconjugation reactivity. Moisture exposure accelerates both impurity generation and random hydrolysis of polyester backbones. Equilibrate sealed vials completely to room temperature inside a desiccator before opening to prevent water‑vapour‑induced sample contamination. Prepare working solutions with anhydrous organic solvents immediately before experiments; long‑term storage of dissolved polymer stocks is not recommended. This product is intended for laboratory‑only research and is not authorized for human clinical application.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.