Alkyne-Poly(L-Glutamic Acid), MW 2.5K is an alkyne-functionalized, carboxyl-rich poly(amino acid) based on poly(L-glutamic acid). It combines terminal alkyne functionality with a compact polyanionic polymer chain specifically for click chemistry, bioconjugation, and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) provides a biodegradable polymer framework with multiple pendant carboxyl groups.
- MW 2.5K: The low molecular weight polymer specifically provides a compact poly(L-glutamic acid) chain with multiple carboxyl groups.
- Terminal Alkyne Group: Provides a reactive alkyne handle specifically for selective click chemistry with compatible azide-containing molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with compatible azide-functionalized molecules.
- Carboxyl-Rich Structure: Pendant carboxyl groups provide additional sites for chemical modification and conjugation.
- Polyanionic Character: Deprotonated carboxyl groups specifically provide negative charge under suitable pH conditions.
- Multifunctional Platform: Combines terminal alkyne reactivity with the carboxyl-rich properties of poly(L-glutamic acid).
- Bioconjugation Platform: Enables attachment of compatible azide-functionalized peptides, proteins, ligands, dyes, polymers, and other molecules.
Applications
- Click Chemistry: Terminal alkyne supports CuAAC reactions with compatible azide-functionalized molecules.
- Bioconjugation: Enables attachment of compatible azide-containing biomolecules, ligands, dyes, and other functional compounds.
- Polymer Functionalization: Provides an alkyne handle and pendant carboxyl groups for preparing multifunctional polymer conjugates.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible polymeric and nanoparticle systems.
- Surface Modification: Enables development of functional polymer coatings and modified surfaces through compatible click chemistry.
- Ligand Conjugation: Supports attachment of compatible azide-functionalized ligands for research applications.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Alkyne-Poly(L-Glutamic Acid), MW 2.5K combines a compact, carboxyl-rich poly(amino acid) chain with terminal alkyne functionality and specifically supports CuAAC click chemistry, bioconjugation, polymer functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
