Ald-CH2-PEG4-NHBoc

Ald-CH2-PEG4-NHBoc

Ald-CH2-PEG4-NHBoc is a high-purity heterobifunctional PEG linker with an aldehyde group for chemoselective oxime or hydrazone ligation and a Boc-protected amine for controlled activation. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The Boc group keeps the amine protected until mild acidic deprotection is performed, allowing for orthogonal, stepwise conjugation strategies.

Key Features and Benefits

• Aldehyde Group: Reacts with aminooxy or hydrazide groups to form stable oxime or hydrazone bonds under mild conditions.

• Boc-Protected Amine: Stable under neutral and basic conditions; removable under mild acidic conditions to reveal a primary amine.

• PEG4 Spacer: Enhances water solubility, flexibility, and accessibility of reactive groups.

• Heterobifunctional Design: Enables orthogonal and sequential modification strategies.

• High Purity: Supplied at >95% purity for consistent and reproducible results.

Applications

• Stepwise Bioconjugation: Protect the amine until the desired stage for controlled functionalization.

• Protein and Peptide Modification: Couple aldehyde-reactive partners before amine activation.

• Nanoparticle and Surface Functionalization: Introduce aldehyde groups with latent amine functionality.

• Drug Delivery Systems: Enable sequential payload attachment with controlled activation steps.

• Diagnostic and Imaging Probes: Prepare multifunctional probes with orthogonal chemistries.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure to maintain reactivity.

Ald-CH2-PEG4-NHBoc combines aldehyde reactivity with a protected amine in a hydrophilic PEG4 framework, offering flexibility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.