Ald-CH2-PEG2-NHBoc
This high-purity PEG linker features an aldehyde for oxime or hydrazone ligation and a Boc-protected amine for selective acidic deprotection. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance for especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Aldehyde Group – Enables chemoselective oxime/hydrazone formation with aminooxy or hydrazide partners.
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Boc-Protected Amine – Allows selective deprotection for controlled sequential conjugations.
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PEG2 Spacer – Improves solubility, flexibility, and reduces steric hindrance.
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Orthogonal Reactivity – Supports multi-step, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible results.
Applications
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Sequential and orthogonal conjugation strategies
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) linker chemistry
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Diagnostic and imaging probe synthesis
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure
This aldehyde–Boc PEG2 linker is designed for orthogonal bioconjugation, providing excellent solubility, flexibility, and high purity for especially efficient and reproducible conjugation in both aqueous and organic systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
