Ald-CH2-PEG2-Azide
This product is a heterobifunctional PEG linker containing an aldehyde group, a PEG2 spacer, and a terminal azide. It specifically enables carbonyl conjugation and bioorthogonal click chemistry, offering dual reactivity in a compact and soluble scaffold.
Key Features and Benefits
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Aldehyde Group: Couples with amines or hydrazides via reductive amination or oxime ligation.
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Azide Group: Reacts with alkynes in CuAAC or SPAAC click chemistry.
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PEG2 Spacer: Provides solubility and reduces steric hindrance.
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Dual Reactivity: Combines aldehyde-based conjugation with azide click chemistry.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications
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Bioconjugation: Links aldehyde- and alkyne-modified molecules in orthogonal systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with orthogonal handles for conjugation.
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Material Science: Functionalizes nanoparticles and polymers with aldehyde and azide groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates aldehyde conjugation with azide click chemistry in a PEG2 scaffold, specifically offering versatility for synthesis, probes, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
