Ald-benzyl-PEG4-propargyl
This product is a heterobifunctional PEG linker featuring an aldehyde-functionalized benzyl group and a terminal propargyl (alkyne) for click chemistry. The PEG4 spacer improves solubility and flexibility, making it especially effective for multifunctional bioconjugation, probe design, and advanced drug delivery systems.
Key Features and Benefits:
-
Aldehyde-Benzyl Group: Enables oxime or hydrazone ligation with aminooxy/hydrazide partners.
-
Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
-
PEG4 Spacer: Provides solubility, hydrophilicity, and steric spacing.
-
Orthogonal Reactivity: Combines carbonyl- and alkyne-based conjugation strategies.
-
High Purity: Ensures reproducible results in advanced workflows.
Applications:
-
Bioconjugation: Couples biomolecules through aldehyde and alkyne handles.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Provides PEGylated linkers for controlled release.
-
Synthetic Chemistry: Useful in orthogonal, multi-step synthesis.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect aldehyde from premature oxidation.
This product combines aldehyde reactivity with click-ready alkyne functionality in a PEG4 scaffold, specifically offering orthogonal chemistry for advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
