Ald-benzyl-amide-PEG3-propargyl
Ald-benzyl-amide-PEG3-propargyl is a high-purity heterobifunctional PEG linker with an aldehyde group for oxime or hydrazone ligation and a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG3 spacer enhances solubility, provides flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This dual-reactive design allows orthogonal, stepwise assembly of multifunctional biomolecules, drug conjugates, and advanced materials.
Key Features and Benefits
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Aldehyde Group: Couples chemoselectively with aminooxy- or hydrazide-containing molecules via oxime or hydrazone bonds.
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Terminal Alkyne: Reacts with azides through CuAAC click chemistry.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive sites.
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Heterobifunctional Design: Enables orthogonal conjugation strategies for complex bioconjugates.
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High Purity: Supplied at >95% purity for reliable, reproducible results.
Applications
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Stepwise Bioconjugation: Sequentially attach carbonyl-reactive and azide-containing components.
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Protein and Peptide Modification: Introduce aldehyde and alkyne handles for dual labeling.
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Nanoparticle Functionalization: Create multifunctional surfaces for targeting and detection.
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Drug Delivery Systems: Build linkers for stable attachment and triggered release.
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Diagnostic Probes: Develop advanced imaging and sensing agents.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
Ald-benzyl-amide-PEG3-propargyl combines aldehyde and alkyne functionalities in a PEG3 spacer, enabling orthogonal, high-efficiency bioconjugation specifically for drug delivery, diagnostics, and multifunctional biomaterials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
